KPV | Research Use Only

What it is

KPV is a short tripeptide composed of lysine, proline, and valine. In the research literature, it is commonly described as the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) and is studied for its signaling and inflammation-related research relevance.

Origins and scientific context

KPV is derived from the terminal amino acid sequence of α-MSH, and deletion studies described in the literature identify K-P-V as the minimum effective C-terminal sequence associated with key biologic activity in these models. Research has also examined KPV analogues and modified forms to better understand its mechanistic behavior.

Molecular profile

KPV is commonly identified as Lys-Pro-Val. PubChem-linked records list the KPV tripeptide with a molecular formula of C16H30N4O4 and a molecular weight of about 342.43 g/mol.

Scientific overview

In simplified terms, KPV is used in research to study peptide transport, inflammation-related signaling, and cellular response pathways. Published studies report that KPV uptake can be mediated by the PepT1 transporter and that it has been investigated in intestinal and epithelial experimental models for its effects on inflammatory signaling responses.

What researchers study with KPV

Key research focus areas often include
• Peptide transporter activity such as PepT1-mediated uptake
• Inflammation-related signaling in intestinal and epithelial models
• α-MSH fragment activity and melanocortin-related pathway research
• Comparative studies of KPV and related analogues

Regulatory and compliance notice

Research Use Only. Not for human or veterinary use. This description is provided for scientific context and must not be used to market KPV for diagnosis, cure, mitigation, treatment, or prevention of disease.

Citations and references

PubChem-linked KPV tripeptide entry, includes molecular formula and molecular information.

Dalmasso et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation, study describing KPV as a tripeptide Lys-Pro-Val and examining PepT1-mediated uptake.

Land et al. Mechanism of KPV action and a role for MC3R agonists, paper describing KPV as the minimum effective C-terminal α-MSH sequence and discussing analogues.

Xiao et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis, describes KPV as a naturally occurring tripeptide and its research context.