5 Amino 1Mg

5-Amino-1Mg | Research Use Only

What it is

5-Amino-1Mg, commonly written as 5-amino-1-methylquinolinium, is a small-molecule research compound studied primarily as an inhibitor of nicotinamide N-methyltransferase, or NNMT. NNMT is an enzyme involved in nicotinamide metabolism and methylation pathways and has been investigated in research related to cellular energy balance, adipose biology, aging, and metabolic regulation. Sources: PubChem compound record, Neelakantan et al. PMC.

Origins and scientific context

Interest in 5-Amino-1MQ grew from broader research into NNMT as a metabolic regulator and experimental target in obesity, aging, and disease biology. Published studies describe methylquinolinium-based NNMT inhibitors, including 5-amino-1-methylquinolinium, as selective and membrane-permeable compounds used in preclinical models to explore how NNMT influences nicotinamide salvage, methyl donor balance, and downstream cellular responses. Source: Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

Molecular profile

PubChem lists 5-amino-1-methylquinolinium with molecular formula C10H11N2+ and molecular weight 159.21 g/mol. Related salt forms, including iodide forms used in some laboratory contexts, may appear in separate records and should not be confused with the core cation itself. Sources: PubChem 5-Amino-1-methylquinolinium, PubChem NNMTi iodide record.

Scientific overview

5-Amino-1MQ is studied for its ability to inhibit NNMT, an enzyme that converts nicotinamide into 1-methylnicotinamide using S-adenosyl-L-methionine as a methyl donor. In research settings, NNMT inhibition has been explored because NNMT activity may influence NAD-related metabolism, methylation balance, adipocyte biology, mitochondrial function, and cellular stress responses. Preclinical papers involving 5-amino-1-methylquinolinium and related NNMT inhibitors have examined effects in cell systems and animal models, especially in metabolic and muscle-aging research. Sources: Neelakantan et al. 2018, Neelakantan et al. 2019, Babula et al. 2024.

What researchers study with 5-Amino-1MQ

Common research focus areas include
• NNMT enzyme inhibition and nicotinamide metabolism
• NAD salvage pathway biology and methyl donor utilization
• Adipocyte metabolism, obesity-related pathways, and metabolic syndrome models
• Skeletal muscle regeneration, mitochondrial adaptations, and aging-related biology

Sources: Neelakantan et al. 2018, Neelakantan et al. 2019, Babula et al. 2024.

Regulatory and compliance notice

Research Use Only. Not for human or veterinary use. This material is intended strictly for laboratory and scientific research applications. It is not approved by the FDA for use as a drug, food, or dietary supplement, and it should not be marketed with claims implying unapproved human use. Source: FDA RUO/IUO guidance.

Citations and references

PubChem. 5-Amino-1-methylquinolinium compound record, includes formula and molecular weight.
https://pubchem.ncbi.nlm.nih.gov/compound/5-Amino-1-methylquinolinium

PubChem. NNMTi related record, includes iodide/salt-form identifiers.
https://pubchem.ncbi.nlm.nih.gov/compound/NNMTi

Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/

Neelakantan H, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6469996/

Babula JAJ, et al. Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11622326/

FDA. Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use Only.
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/distribution-in-vitro-diagnostic-products-labeled-research-use-only-or-investigational-use-only