Kisspeptin-10 | Research Use Only

What it is

Kisspeptin-10 is a decapeptide fragment derived from the KISS1 gene product and is widely studied as an endogenous ligand of the kisspeptin receptor, KISS1R also known as GPR54. In the scientific literature, kisspeptin-10 is described as the smallest endogenous kisspeptin fragment that retains strong receptor-binding and agonist activity, which is why it is commonly used in reproductive endocrinology and receptor-signaling research.

Origins and scientific context

Kisspeptins are generated from the larger KISS1 precursor peptide, and shorter active fragments including kisspeptin-54, kisspeptin-14, kisspeptin-13, and kisspeptin-10 can be produced from that precursor. Research papers describe kisspeptin-10 as a KISS1-derived decapeptide identified from the primary translation product and studied because it preserves key biologic activity at KISS1R despite its smaller size.

Molecular profile

Kisspeptin-10 is commonly identified as the C-terminal decapeptide amide of kisspeptin. PubChem lists human kisspeptin-10 with the molecular formula C63H83N17O14 and a molecular weight of approximately 1302.4 g/mol.

Scientific overview

In simplified terms, kisspeptin-10 is used in research to study KISS1R signaling, hypothalamic-pituitary-gonadal axis regulation, and neuroendocrine control of gonadotropin release. Reviews describe kisspeptin signaling as a critical regulator of reproductive axis function, and human studies report that kisspeptin-10 can stimulate gonadotropin release in defined experimental settings.

What researchers study with Kisspeptin-10

Key research focus areas often include
• KISS1R or GPR54 receptor signaling pathways
• Hypothalamic-pituitary-gonadal axis models
• Gonadotropin release and neuroendocrine response studies
• Comparative studies of kisspeptin isoforms and analogs

Regulatory and compliance notice

Research Use Only. Not for human or veterinary use. This description is provided for scientific context and must not be used to market kisspeptin-10 for diagnosis, cure, mitigation, treatment, or prevention of disease.

Citations and references

PubChem compound entry for Kisspeptin-10, includes molecular formula and molecular weight.

Bilban et al. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts, identifies Kisspeptin-10 as a KISS1-derived decapeptide.

Clarke and Dhillo. Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders, review covering kisspeptin receptor biology and reproductive signaling context.

Lee et al. Molecular Interaction Between Kisspeptin Decapeptide and Phospholipid Membranes, describes Kisspeptin-10 as the C-terminal decapeptide amide of kisspeptin and an endogenous ligand for GPR54.

Jayasena et al. The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans, study describing gonadotropin responses to kisspeptin-10 in humans.