Sermorelin | Research Use Only

What it is

Sermorelin is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal segment of human growth hormone-releasing hormone, commonly written as GHRH(1-29)-NH2. In scientific references, it is described as the shortest synthetic fragment of GHRH that retains full biologic activity, which is why it is commonly studied in pituitary and growth hormone signaling research.

Origins and scientific context

Sermorelin is not a random analog but a synthetic preparation of the active amino-terminal portion of endogenous human GHRH. NCBI MeSH identifies sermorelin as the biologically active fragment of human growth hormone-releasing factor consisting of GHRH(1-29)-amide, and review literature describes it as a 29-amino-acid analogue of human GHRH used in diagnostic and endocrine research contexts.

Molecular profile

PubChem lists Sermorelin with the molecular formula C149H246N44O42S, while Sermorelin Acetate is listed separately as the acetate salt form. PubChem also describes sermorelin acetate as the acetate salt of an amidated synthetic 29-amino-acid peptide corresponding to GRF 1-29 NH2.

Scientific overview

In simplified terms, sermorelin is used in research to study GHRH receptor signaling, anterior pituitary growth hormone release, and endocrine response patterns. Published studies using GHRH(1-29)-NH2 describe it as a potent stimulator of growth hormone release in experimental and diagnostic settings, making it useful in pituitary-response and growth-hormone-axis research.

What researchers study with Sermorelin

Key research focus areas often include
• GHRH receptor and pituitary signaling pathways
• Growth hormone release and endocrine-response models
• Comparative studies of GHRH fragments and analogs
• Diagnostic and mechanistic studies involving the GH axis

Regulatory and compliance notice

Research Use Only. Not for human or veterinary use. This description is provided for scientific context and must not be used to market sermorelin for diagnosis, cure, mitigation, treatment, or prevention of disease.

Citations and references

PubChem compound entry for Sermorelin, includes molecular formula and compound information.

PubChem compound entry for Sermorelin Acetate, identifies the acetate salt form of sermorelin.

NCBI MeSH entry for Sermorelin, describes it as the biologically active fragment of human growth hormone-releasing factor consisting of GHRH(1-29)-amide.

Prakash et al. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency, describes sermorelin as a 29-amino-acid analogue of human GHRH and the shortest synthetic peptide with full biologic activity of GHRH.

Grossman et al. The Use of Growth Hormone-Releasing Hormone in the Diagnosis of Growth Hormone Deficiency, describes use of the GHRH(1-29)NH2 analogue in diagnostic endocrine testing.

Wilton et al. study of GHRH(1-29)-NH2 in healthy men, describing growth hormone release after administration of the analogue.