SLU-PP-332 | Research Use Only

What it is

SLU-PP-332 is a synthetic small molecule studied in research settings as a pan estrogen-related receptor agonist, with activity across ERRα, ERRβ, and ERRγ. In the published literature, it is described as an exercise-mimetic research compound because of its ability to activate ERR-driven transcriptional and metabolic programs in experimental systems.

Origins and scientific context

SLU-PP-332 was developed as a chemical tool to investigate estrogen-related receptor biology, particularly the role of ERR signaling in mitochondrial function, oxidative metabolism, and skeletal muscle physiology. Recent peer-reviewed studies from academic groups describe it as a research agonist with sufficient pharmacokinetic properties for in vivo experimental use in mice.

Molecular profile

PubChem lists SLU-PP-332 with the molecular formula C18H14N2O2. PubChem also identifies the compound under the chemical name 4-hydroxy-N’-(naphthalen-2-ylmethylene)benzohydrazide, reflecting its small-molecule structure rather than a peptide or protein format.

Scientific overview

In simplified terms, SLU-PP-332 is used in research to study ERR-mediated metabolic signaling, mitochondrial respiration, and oxidative skeletal muscle programming. Experimental studies report that SLU-PP-332 increases mitochondrial function and cellular respiration in skeletal muscle cell models, induces an ERRα-dependent aerobic exercise response, and in mouse studies has been associated with increased oxidative muscle fibers and enhanced endurance-related outcomes.

What researchers study with SLU-PP-332

Key research focus areas often include
• ERRα, ERRβ, and ERRγ receptor signaling
• Mitochondrial function and oxidative metabolism
• Skeletal muscle fiber-type and endurance-response models
• Metabolic syndrome, obesity, and cardiometabolic pathway research

Regulatory and compliance notice

Research Use Only. Not for human or veterinary use. This description is provided for scientific context and must not be used to market SLU-PP-332 for diagnosis, cure, mitigation, treatment, or prevention of disease. Current published work describes it as an experimental research compound and chemical tool, not an approved general-use consumer product.

Citations and references

PubChem compound entry for SLU-PP-332, includes molecular formula and compound identification.

Billon et al. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity, study describing SLU-PP-332 as a pan-ERR agonist and exercise-mimetic research compound.

Billon et al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome, study describing SLU-PP-332 in metabolic disease and obesity research models.

Xu et al. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Augmented Cardiac Fatty Acid Oxidation and Mitochondrial Function, study covering SLU-PP-332 in cardiovascular and metabolic signaling research.